In brief: A site built around the 2024 launch of ESM3 now needs to explain the broader protein AI ecosystem, updated official links and newer structure-prediction and representation tools.
From the 2024 announcement to peer-reviewed publication
ESM3 was publicly introduced in June 2024. Its influential study, “Simulating 500 million years of evolution with a language model,” appeared in Science in 2025. Do not blur the announcement and peer-reviewed publication dates.
The move to Biohub
EvolutionaryScale is now part of Biohub. Official ESM access, documentation and model cards have moved into the Biohub ecosystem. Tutorials should reference the maintained Biohub/esm repository, not assume historical service endpoints are still correct.
Three distinct research tools
ESM3 supports multimodal generative protein design. ESMC emphasizes representations and embeddings. ESMFold2 focuses on all-atom structural prediction. The ESM Atlas allows exploration of a large map of sequence and predicted-structure space.
What researchers should update in older notebooks
Recheck package versions, imports, endpoint URLs, model names, hardware requirements, licensing and validation statements. Do not mechanically update a URL while leaving an ESM2 call or fabricated utility class in place.
Editorial note
This article summarizes publicly documented capabilities available as of October 2026, not future roadmap promises. See linked model cards for subsequent changes.
Primary sources and further reading
Editorial review: October 2026. This guide is educational. Model availability and APIs may change; confirm exact versions in the linked documentation. Generated structures and sequences require independent scientific validation.