Updated for 2026: A 2026 troubleshooting reference for typical ESM3 environment, authentication, payload and memory problems.
Module import failed
Verify that the esm package is installed in the interpreter launching the script. Check the SDK version and exact official import path; SDK interfaces change. Do not create fictional class aliases to get examples to run.
Authentication or quota failed
Confirm the Biohub endpoint, token, account entitlements and model availability. Rotate exposed credentials. Budget and quota errors should result in a graceful explanation, not repeated retry storms.
Out-of-memory error
Reduce sequence length where scientifically appropriate, batch size or concurrent requests. Check the model footprint and hardware requirements. Record changes because some optimizations can alter numerical outcomes.
Invalid or confusing output
Inspect input formatting, tokenization, model choice and output representation. A generated sequence should not be reported as a structure prediction, assay measurement or verified therapeutic result.
Evidence and further reading
Primary sources: Biohub ESM3 model, Biohub maintained ESM repository, and Biohub learning resources. Check model cards and release notes for version-specific instructions.
Editorial note: Updated October 2026. Distinguish scientific literature and current product documentation from speculative applications; verify current API details before running code.